Transactions of Nanjing University of Aeronautics & Astronautics
纳米二氧化钛吸入对小鼠肺部和血清生化指标的影响
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
The effect of inhaled nanoTiO2 on lung histology and serum biochemic al indexes is evaluated in healthy and adult Kunming mice (eight in each group) after exposure to TiO2 aerosols (1 500 mg／m3) in a sealed chamber. Ano ther e ight mice are exposed to indoor air to be served as a control group. Lung tissue and blood are collected after euthanizing the animals. The results show that la c tate dehydrogenase (LDH) activity increases in all experimental groups. Alanine aminotransferase(ALT) activity and blood urea nitrogen (BUN) levels are increase d in the group exposed to TiO2 aerosols for 28 d, and creatinine(Cr) level s are increased in 14 d and 28 d samples (P<005). No obvious changes are observed in other serum indexes. Lungs of mice exposed to 28 d exposure show significant but moderate increase in pulmonary inflammatio n, and many TiO2 particles are found in the interstitium of pulmonary alve oli.
Keywords:
Project Supported:
Clc Number:
Mobile website
