Carbon fiber-reinforced polymer （CFRP） is widely used in aerospace applications. This kind of material may face the threat of high-velocity impact in the process of dedicated service， and the relevant research mainly considers the impact resistance of the material， and lacks the high-velocity impact damage monitoring research of CFRP. To solve this problem， a real high-velocity impact damage experiment and structural health monitoring （SHM） method of CFRP plate based on piezoelectric guided wave is proposed. The results show that CFRP has obvious perforation damage and fiber breakage when high-velocity impact occurs. It is also proved that guided wave SHM technology can be effectively used in the monitoring of such damage， and the damage can be reflected by quantifying the signal changes and damage index （DI）. It provides a reference for further research on guided wave structure monitoring of high/hyper-velocity impact damage of CFRP.