The seismic safety of offshore wind turbines is an important issue that needs to be solved urgently. Based on a unified computing framework， this paper develops a set of seawater-seabed-wind turbine zoning coupling analysis methods. A 5 MW wind turbine and a site analysis model are established， and a seismic wave is selected to analyze the changes in the seismic response of offshore monopile wind turbines under the change of seawater depth， seabed wave velocity and seismic wave incidence angle. The analysis results show that when the seawater increases to a certain depth， the seismic response of the wind turbine increases. The shear wave velocity of the seabed affects the bending moment and displacement at the bottom of the tower. When the angle of incidence increases， the vertical displacement and the acceleration of the top of the tower increase in varying degrees.